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American Chemical Society, Journal of Medicinal Chemistry, 24(57), p. 10455-10463, 2014

DOI: 10.1021/jm501501a

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N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

Journal article published in 2014 by Oscar M. Bautista-Aguilera, Abdelouahid Samadi, Mourad Chioua, Katarina Nikolic, Slavica Filipic, Danica Agbaba, Elena Soriano, Lucía de Andrés, L. de Andrés, María Isabel Rodríguez-Franco ORCID, Stefano Alcaro, Rona R. Ramsay, Francesco Ortuso, Matilde Yañez, José L. Marco-Contelles
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Based on N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234), and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.