Green tea is an excellent source of health-promoting polyphenols, such as catechins, being epigallocatechin gallate (EGCG) the most potent and abundant catechin present [1]. Its antioxidant activity is at least 100 fold higher than vitamin C, thus its highly effective as antimicrobial, antiviral, antidiabetic or anticarcinogenic agent [2]. Due to its features, EGCG is highly attractive to be used in food, pharmaceutical or cosmetic industry [3]. Nevertheless, this application can be hindered due to the chemical instability of the catechin, leading to inefficient systemic delivery and thus poor bioavailability. One way to overcome this problem and to protect EGCG from unfavorable environmental conditions is the encapsulation of the catechin into microsystems in order to retain EGCG's structural integrity. Thus, the aim of the present work was to study the encapsulation of EGCG in three natural origin carrier materials, namely modified n-octenyl succinate anhydride (OSA) starch, soybean lecithin and barley β-glucan, by Particles from Gas Saturated Solutions (PGSS)-drying technique. PGSS-drying represents an attractive alternative to create microparticles with controlled particle size, avoiding thermal degradation and providing an inert atmosphere [4]. Particles obtained were analyzed in terms of morphology, particle size, structural characterization, encapsulation efficiency (EE) and EGCG release profiles. The stability of EGCG incorporated into the natural origin matrices was studied by measuring its antioxidant activity (AA) to evaluate the efficacy of the encapsulation technique. Dry microparticles with EE around 80% were obtained, with maintenance of AA. Moreover, the solid formulations presented higher storage stability in comparison with non-encapsulated EGCG. Polysaccharide-based particles provided burst release of EGCG while lecithin provided a more sustained release of the catechin. In conclusion, PGSS-drying proved to be a suitable method to formulate EGCG-loaded particles with improved stability.