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Wiley, Angewandte Chemie, 37(126), p. 10075-10079

DOI: 10.1002/ange.201405726

Wiley, Angewandte Chemie International Edition, 37(53), p. 9917-9921

DOI: 10.1002/anie.201405726

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Reversible Supramolecular Assembly at Specific DNA Sites: Nickel-Promoted Bivalent DNA Binding with Designed Peptide and Bipyridyl–Bis(benzamidine) Components

Journal article published in 2014 by Mateo I. Sánchez, Jesús Mosquera, M. Eugenio Vázquez, M. Eugenio Vázquez, José L. Mascareñas ORCID
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This paper is available in a repository.

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Abstract

At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.