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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(50), p. 3920-3922, 2006

DOI: 10.1128/aac.00223-06

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Novel Streptomycin Resistance Gene from Mycobacterium fortuitum

Journal article published in 2006 by Santiago Ramón-García ORCID, Isabel Otal, Carlos Martín ORCID, Rafael Gómez-Lus, José A. Aínsa ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We have isolated the aph ( 3 ") -Ic gene, encoding an aminoglycoside 3"- O -phosphotransferase [APH(3")-Ic], from a genomic library of an environmental Mycobacterium fortuitum strain, selecting for streptomycin resistance. APH(3")-Ic phosphorylates and inactivates streptomycin. Similar genes have been described in Streptomyces griseus and plasmid RSF1010. It is also present in some M. fortuitum clinical isolates.