Contrast-Enhancement (CE) is an innovative approach, used in radiological framework, to evaluate the vascularization of the diseases. This non-invasive method determines the nature of a diseases, analysing the perfusion' dynamic of contrast media in the tissues. In this paper we present an innovative tool named DyCoH (Dynamic Contrast Enhancement). This software, being specifically designed for this type of analysis, provides to medical doctor, in a very user-friendly framework, all the information needed to perform the CE analysis. DyCoH produces four inspectionable colour-maps that radiologists can use to identify the most relevant areas over which dynamically evaluates the contrast enhancement curve. However, the most interesting feature of DyCoH is its capability to manage, into a single framework, DICOM images produced by US, CT and MR of different vendors, allowing to support many types of clinical tests and to compare results provided by different diagnostic devices. Clinical tests have shown the effectiveness of the software and its capability to concretely support CE diagnoses.