Nanostructured iridium oxide-carbon nanotubes hybrids (IrOx-CNTs) deposited as thin film by dynamic electrochemical methods are suggested as novel materials for neural electrodes. Single-walled carbon nanotubes (SWCNTs) serve as scaffold to grow the oxide, yielding a tridimensional structure with improved physical, chemical and electrical properties, besides high biocompatibility. In biological environments, SWCNTs encapsulation by IrOx makes more resistant electrodes and prevents the nanotubes release to the media, preventing cellular toxicity. Chemical, electrochemical, structural and surface characterization of the hybrids has been accomplished. The high performance of the material in electrochemical measurements and the significant increase in cathodal Charge Storage Capacity (CSCc) obtained for the hybrid in comparison with bare IrOx, represent a significant advance in electric field application in bio systems while its cyclability is also an order of magnitude larger than pure IrOx. Moreover, our experiments using in vitro neuronal cultures suggest a high biocompatibility for IrOx-CNTs coatings, and full functionality of neurons, validating this material for the use as neural electrodes.