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Wiley Open Access, CPT: Pharmacometrics and Systems Pharmacology, 6(4), p. 316-319, 2015

DOI: 10.1002/psp4.57

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Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development

Journal article published in 2015 by Mj Swat, S. Moodie, Sm Wimalaratne ORCID, Nr Kristensen, M. Lavielle, A. Mari, P. Magni, Mk Smith, R. Bizzotto, L. Pasotti, E. Mezzalana, E. Comets, C. Sarr, N. Terranova, E. Blaudez and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The lack of a common exchange format for mathematical models in pharmacometrics has been a long-standing problem. Such a format has the potential to increase productivity and analysis quality, simplify the handling of complex workflows, ensure reproducibility of research, and facilitate the reuse of existing model resources. Pharmacometrics Markup Language (PharmML), currently under development by the Drug Disease Model Resources (DDMoRe) consortium, is intended to become an exchange standard in pharmacometrics by providing means to encode models, trial designs, and modeling steps.