Dental impressions disinfection is important to reduce the risk of cross contamination but this process may produce dimensional distortions. Peracetic acid is a disinfectant agent with several favorable characteristics yet underutilized in Dentistry. The aim of this paper is to compare the dimensional stability of casts obtained from addition silicone and polyether impressions that were immersed for 10 minutes in a solution of 0.2% peracetic acid or 1% sodium hypochlorite. Sixty samples in type IV gypsum were produced after a master cast that simulated a full crown preparation of a maxillary premolar. Samples were divided in 6 groups (n = 10) according to the impression material and disinfection agent: Group AC - addition silicone control (without disinfectant); Group APA - addition silicone + 0.2% peracetic acid; Group AH - addition silicone + 1% sodium hypochlorite; Group PC - polyether control (without disinfectant); Group PPA - polyether + 0.2% peracetic acid; Group PH - polyether + 1% sodium hypochlorite. Cast height, base and top diameter were measured and a mean value was obtained for each sample and group all data was statistically analyzed (ANOVA, p < 0.05). There was not a signifcant statistical difference between addition silicone and polyether impressions regardless of the disinfectant materials. It can be concluded that disinfection with the proposed agents did not produce signifcant alterations of the impressions and the peracetic acid could be considered a reliable material to disinfect dental molds. Keywords: Dimensional stability, Impression materials, Peracetic acid. How to cite this article: Queiroz DA, Peçanha MM, Neves ACC, Frizzera F, Tonetto MR, Silva-Concílio LR. Infuence of Disinfection with Peracetic Acid and Hypochlorite in Dimensional Alterations of Casts obtained from Addition Silicone and Polyether Impressions. J Contemp Dent Pract 2013;14(6):1100-1105. Source of support: Nil Confict of interest: None declared.