Published in
American Medical Association, Journal of the American Medical Association, 24(314), p. 2632
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Ovarian Suppression With Triptorelin During Adjuvant Breast Cancer Chemotherapy and Long-term Ovarian Function, Pregnancies, and Disease-Free Survival: A Randomized Clinical Trial
Journal article published in 2015 by
Matteo Lambertini,
Luca Boni,
Andrea Michelotti,
Teresa Gamucci,
Tiziana Scotto,
Stefania Gori,
Monica Giordano,
Ornella Garrone,
Alessia Levaggi,
Francesca Poggio 
,
Sara Giraudi,
Claudia Bighin,
Carlo Vecchio,
Mario Roberto Sertoli,
Paolo Pronzato
and other authors.
,
Sara Giraudi,
Claudia Bighin,
Carlo Vecchio,
Mario Roberto Sertoli,
Paolo Pronzato
and other authors.
This paper is made freely available by the publisher.
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Abstract
Whether the administration of luteinizing hormone-releasing hormone analogues (LHRHa) during chemotherapy is a reliable strategy to preserve ovarian function is controversial owing to both the lack of data on long-term ovarian function and pregnancies and the safety concerns about the potential negative interactions between endocrine therapy and chemotherapy.