Allergic contact dermatitis is a delayed-type hypersensitivity reaction mediated by hapten-specific T cells. Many cell types, inflammatory mediators and cytokines are involved in this reaction. Contact hypersensitivity is a self-limited reaction and can be regulated at different levels. Because it is known that disturbances in the immune system underpin the onset of depression and that antidepressant drugs have immunomodulatory effects, it can be hypothesized that antidepressants may have some efficacy in the treatment of contact hypersensitivity. There are some reports on the effectiveness of antidepressants in the inhibition of cutaneous sensitization in mice, and the aim of this narrative review is to assess the evidence for the effectiveness of antidepressant drugs in reducing the recurrence of contact hypersensitivity reactions.