Proteoglycans and Glycosaminoglycans Improve Toughness of Biocompatible Double Network Hydrogels
Journal article published in 2013 by
Yu Zhao,
Tasuku Nakajima,
Jing Yang,
Takayuki Kurokawa 
,
Jian Liu,
Jishun Lu,
Shuji Mizumoto,
Kazuyuki Sugahara,
Nobuto Kitamura,
Kazunori Yasuda,
A. U. D. Daniels,
Jian Ping Gong
,
Jian Liu,
Jishun Lu,
Shuji Mizumoto,
Kazuyuki Sugahara,
Nobuto Kitamura,
Kazunori Yasuda,
A. U. D. Daniels,
Jian Ping Gong
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Abstract
Based on the molecular stent concept, a series of tough double-network hydrogels (St-DN gels) made from the components of proteoglycan aggregates - chondroitin sulfate proteoglycans (1), chondroitin sulfate (2), and sodium hyaluronate (3) - are successfully developed in combination with a neutral biocompatible polymer. This work demonstrates a promising method to create biopolymer-based tough hydrogels for biomedical applications.