Published in
American Society of Hematology, Blood, 9(125), p. 1418-1426, 2015
DOI: 10.1182/blood-2014-04-568170
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Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium
Journal article published in 2015 by
Il Ho Jang,
Yi-Fen Lu,
Long Zhao,
Pamela L. Wenzel,
Tsutomu Kume,
Sumon M. Datta,
Natasha Arora,
Jordi Guiu,
Mounia Lagha 
,
Peter G. Kim,
Eun Kyoung Do,
Jae Ho Kim,
Thorsten M. Schlaeger ,
Leonard I. Zon,
Anna Bigas
and other authors.
,
Peter G. Kim,
Eun Kyoung Do,
Jae Ho Kim,
Thorsten M. Schlaeger ,
Leonard I. Zon,
Anna Bigas
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key PointsNotch1 induction promotes specification of hemogenic endothelial cells during embryonic stem cell differentiation. Foxc2 functions downstream of Notch in specification of hemogenic endothelium in mouse and zebrafish embryos.