Hypomelanosis of Ito (HI) though said to be the third-most common neurocutaneus disorder, is rarely reported in paediatric practice in Africa. A high index of suspicion must be maintained in children with cutaneous lesions as a seizure may be the first symptom that may bring the child to attention. A case of HI in a neonate is hereby reported to sen-sitize clinicians about this relatively uncommon disorder