A wide-angle seismic profile between Peigu Tso (85.5°E) and Pumoyong Tso (90.5°E) in southern Tibet, acquired under a joint Sino-French program in 1981, passes through the South Tibetan Detachment System (STDS, the eastern segment of the profile) and the central part of the Tethyan Himalaya (the western segment). We herein reinterpret this wide-angle seismic profile, which has a total length of ~480 km, in order to improve our understanding of the crustal structure of the Tethyan Himalaya. We identify multiple P- and S-wave wide-angle reflections within the crystalline crust and from the Moho, but cannot identify any refracting waves beneath the Moho. We model the structure of P- and S-wave velocity throughout the whole crust, while acknowledging the significant uncertainties that are inherent in many places. A low-wave speed cover sequence may be identified with the Tethyan sedimentary cover (Vp < 5.8 km s-1), from the surface to a depth of (typically) 5-10 km, which is only absent where the profile crosses the Kangmar Dome. It may be presumed that these sedimentary rocks overlay a felsic upper-crustal basement (5.8 < Vp < 6.3 km s-1), which in places extends as far down as 35 km, and which itself overlays a 5-10-km-thick mid-crustal low-velocity zone. Between a depth of 30 and 45 km at the base of the low-velocity zone and the Moho at a depth of ~73 km, the observed velocities gradually increase from 6.2 to 6.8 km s-1. The low-velocity layer (LVL) may consist of a partial melt due to the high geothermal gradients found in the felsic rocks, or of a fluid-rich shear zone as in the ductile channel of a channel flow model. The difference in depth of the LVL between the western (central Tethyan Himalaya) and eastern segments (nearly along the STDS) at the boundary of the Dingye-Mabjia fault, leads to a north-south dip estimate of the LVL of 8.5°, which is consistent with the estimated dip of the MHT obtained from the INDEPTH-I project, and can support the channel flow model. This north-south low dip angle of subduction slab, supports that the subducting Indian lithosphere endured a transition from steep subduction to low-angle subduction, and the subduction slab flattening may be attributed to the break-off of Indian lithosphere slab beneath the Indur-Zurpo suture.