Introduction: Physical disability, especially in childhood and adolescence can cause major psychological problems such as depression and anxiety. Burden of landmine in western border cities of Iran caused many disabled survivors through the years after Iran-Iraq war. Aims: To investigate the potential association of disability of activities of daily living and symptoms of depression and anxiety in adolescents’ affected of post war landmine in Iran. Methods: This study employed two questionnaires for 35 adolescents’ survivors of mine explosions; the prevalence of anxiety and depressive symptoms was examined using the Hopkins Symptom Checklist-25 (HSCL-25) and the ability to perform activities of daily living (ADL) was measured by the Barthel index questionnaire. In addition, the association between anxiety and depression with demographic characteristics and activities of daily living was estimated. Results: Maximum independency was in activities of feeding, bowels, bathing and grooming while highest dependency was in activities of mobility, stairs and dressing. All of the cases have shown depression and the prevalence of anxiety was 31 (88.6%). An analysis of the data reveals significant association between activities of daily living included dressing, feeding, grooming and bathing with depression and anxiety (p<0.05). Although eye injured cases had the most complete independency (50%) in ADL but a significant direct relation was observed between eye impairment and depression (p=0.050). Conclusion: Overall, the study suggested that adolescents with physical disability due to landmine explosion may be suffering from depression and anxiety.