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Wiley-VCH Verlag, ChemInform, 21(46), p. no-no, 2015

DOI: 10.1002/chin.201521064

Wiley, Angewandte Chemie International Edition, 1(54), p. 263-266, 2014

DOI: 10.1002/anie.201409595

Wiley, Angewandte Chemie, 1(127), p. 265-268, 2014

DOI: 10.1002/ange.201409595

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Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions

Journal article published in 2014 by Mao Chen, Saki Ichikawa ORCID, Stephen L. Buchwald
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A general, rapid, and efficient method for the copper-catalyzed Finkelstein reaction of (hetero)aromatics has been developed using continuous flow to generate a variety of aryl iodides. The described method can tolerate a broad spectrum of functional groups, including N-H and O-H groups. Additionally, in lieu of isolation, the aryl iodide solutions were used in two distinct multistep continuous-flow processes (amidation and Mg–I exchange/nucleophilic addition) to demonstrate the flexibility of this method.