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Oxford University Press (OUP), Nephrology Dialysis Transplantation, suppl 4(30), p. iv6-iv16

DOI: 10.1093/ndt/gfv131

Oxford University Press (OUP), Nephrology Dialysis Transplantation, 4(31), p. 680-680

DOI: 10.1093/ndt/gfw024

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Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review

Journal article published in 2015 by Katharina Brück, Vincenzo Capuano, Kitty J. Jager ORCID, P. Jousilahti, C. Helmer, Evangelia Dounousi, M. Metzger, Alexander Kainz, Jb Ruidavets, Dorothea Nitsch, Bongard, W. Koenig, Johan Ärnlov, Johan Ärnl, Dietrich Rothenbacher ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background. Many publications report the prevalence of chronic kidney disease (CKD) in the general population. Comparisons across studies are hampered as CKD prevalence estimations are influenced by study population characteristics and laboratory methods. Methods. For this systematic review, two researchers independently searched PubMed, MEDLINE and EMBASE to identify all original research articles that were published between 1 January 2003 and 1 November 2014 reporting the prevalence of CKD in the European adult general population. Data on study methodology and reporting of CKD prevalence results were independently extracted by two researchers. Results. We identified 82 eligible publications and included 48 publications of individual studies for the data extraction. There was considerable variation in population sample selection. The majority of studies did not report the sampling frame used, and the response ranged from 10 to 87%. With regard to the assessment of kidney function, 67% used a Jaffe assay, whereas 13% used the enzymatic assay for creatinine determination. Isotope dilution mass spectrometry calibration was used in 29%. The CKD-EPI (52%) and MDRD (75%) equations were most often used to estimate glomerular filtration rate (GFR). CKD was defined as estimated GFR (eGFR)