Insects are facing an increasingly tough combination of global change drivers such as habitat fragmentation, agricultural intensification, pollution, or climatic changes. While single-factor studies have yielded considerable insights, multi-factor manipulations have gained momentum over the last years. Nevertheless, most written work to date has remained within particular domains of research, such as “habitat destruction” or “climate change”, and linkages among sub-disciplines within the ecological literature have remained scarce. Here, I provide an overview of the most recent developments in the field, with a focus on main functional groups of insects, but also their interactions with other organisms. All major global change drivers (landscape modification, climate change, agricultural management) are covered both singly and in interaction. The manuscript concludes with concepts on how to statistically and conceptually deal with interactions in experimental and observational work.