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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(50), p. 4170-4173, 2006

DOI: 10.1128/aac.00944-06

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Functional Analysis of DNA Gyrase Mutant Enzymes Carrying Mutations at Position 88 in the A Subunit Found in Clinical Strains of Mycobacterium tuberculosis Resistant to Fluoroquinolones

Journal article published in 2006 by Stéphanie Matrat, Nicolas Veziris ORCID, Claudine Mayer, Vincent Jarlier, Chantal Truffot-Pernot, Juliette Camuset, Elisabeth Bouvet, Emmanuelle Cambau, Alexandra Aubry
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We investigated the enzymatic efficiency and inhibition by quinolones of Mycobacterium tuberculosis DNA gyrases carrying the previously described GyrA G88C mutation and the novel GyrA G88A mutation harbored by two multidrug-resistant clinical strains and reproduced by site-directed mutagenesis. Fluoroquinolone MICs and 50% inhibitory concentrations for both mutants were 2- to 43-fold higher than for the wild type, demonstrating that these mutations confer fluoroquinolone resistance in M. tuberculosis .