Introduction: Prematurity is the leading cause of perinatal death and handicap, and is responsible for at least half of all neonatal deaths. Aim: To analyze the incidence and structure of preterm deliveries at tertiary referral obstetric centre of the region of Vojvodina, in the period of ten years (2000-2009) as well as mode of delivery and contribution of preterm deliveries from pregnancies after IVF. Methods: The birth protocols and patient notes were analyzed for the period of January 1st 2000 - december 31st 2009. Gestational age at the time of delivery, mode of conception, cause of the preterm delivery, number of fetuses and mode of delivery were analyzed. Results: In the observed ten year period were 61416 deliveries. Overall incidence of preterm deliveries was 4,82% (deliveries before 28 weeks, between 28+0 and 33+6 weeks, and between 34 and 37 gestational weeks in all deliveries were 0,35%, 1,4% and 3,23%). No statistically significant rise of overall incidence of PTD was seen. Medically induced preterm deliveries almost doubled in this period, from 16,35% (2000) to 29,19% (2009) (R=0.45, p=0.0002). Preterm deliveries were delivered vaginally in majority of cases. There is a significantly higher incidence of Caesarean section (SC) in medically indicated preterm deliveries. Contribution of multiple pregnancies in the number of all preterm deliveries had a rising trend (R=0.39, p<0.001). Contribution of in vitro concieved pregnancies had a rising trend in the observed period (R=0.40, p<0.001). Conclusion: There was a low rate of PTDs, with a ten year average of only 4.82%, with a rise of trend in medically indicated PTD deliveries, with a relatively constant gestational age structure.