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Elsevier, Bioorganic and Medicinal Chemistry Letters, 17(20), p. 5255-5257

DOI: 10.1016/j.bmcl.2010.06.149

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Synthesis and antituberculosis activity of new fatty acid amides

Journal article published in 2010 by Caroline Da Ros Montes D'Oca, Tatiane Coelho, Tamara Germani Marinho, Carolina Rosa Lopes Hack, Rodrigo da Costa Duarte ORCID, Pedro Almeida da Silva, Marcelo Gonçalves Montes D'Oca, Marcelo Gonçalves Montes D’Oca
This paper is available in a repository.
This paper is available in a repository.

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Abstract

This work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H(37)Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 microg/mL for resistance strains.