Published in
Nature Research, Nature Genetics, 10(40), p. 1204-1210, 2008
DOI: 10.1038/ng.219
Links
- ORCID
- ORCID
- ORCID
- Nature Research | PDF
- [hdl.handle.net]
- [repository.liv.ac.uk]
- [researchonline.lshtm.ac.uk]
- [www.researchgate.net] | PDF
Tools
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
,
Emily Webb,
Gabrielle Sellick,
Ruth Wild,
Kate Sullivan,
Jayaram Vijayakrishnan,
Yufei Wang,
Am M. Pittman,
Nj J. Sunter,
Ag G. Hall,
Mj J. S. Dyer,
Estella Matutes,
Claire Dearden
and other authors.
Full text: Download
Abstract
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.