The prevalence and clinical relevance of p27 and cyclin E immunoreactivity in myelodysplastic syndromes
Journal article published in 2003 by
Giancarlo Pruneri,
N. Fracchialla,
Nicola Fracchiolla 
,
Agostino Cortelezzi,
Maurilio Ponzoni,
Patrick Maisonneuve ,
Giorgio Lambertenghi-Deliliers
,
Agostino Cortelezzi,
Maurilio Ponzoni,
Patrick Maisonneuve ,
Giorgio Lambertenghi-Deliliers
Abstract
We report on p27 and cyclin E immunoreactivity (IR) in 86 patients with myelodysplastic syndromes (MDS). No association was found between cyclin E IR and survival in the whole series. Cyclin E IR was more prevalent in patients with refractory anemia (RA) and RA with ringed sideroblasts (RARS) with poor survival, although this trend was not statistically significant.