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SAGE Publications, Journal of Cerebral Blood Flow and Metabolism, 11(30), p. e1-e7, 2010

DOI: 10.1038/jcbfm.2010.114

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Cerebral 5-HT<sub>2A</sub> Receptor and Serotonin Transporter Binding in Humans Are Not Affected by the val66met BDNF Polymorphism Status or Blood BDNF Levels

Journal article published in 2010 by Anders Bue Klein ORCID, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M. Knudsen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT2A) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT2A receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT2A receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT2A or SERT binding.