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Taylor and Francis Group, Transcription, 1(2), p. 3-8

DOI: 10.4161/trns.2.1.13510

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Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs

Journal article published in 2011 by Achim Leutz ORCID, Ole Pless ORCID, Michael Lappe, Gunnar Dittmar, Elisabeth Kowenz-Leutz
This paper is available in a repository.
This paper is available in a repository.

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Abstract

C/EBPs are implied in an amazing number of cellular functions: C/EBPs regulate tissue and cell type specific gene expression, proliferation, and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence, and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.