Hypermobility of joints is widespread among people. It's a risk factor of the osteoarthrosis. The aim of the research was to stratify the OA risk and type of its course in patients with the family hypermobility of joints on the grounds of clinical and biochemical facts. This work was made in two phases, 209 patients were examined. The first phase of epy research includes emergence of clinical markers of the appearance risk and determining the severity of OA in patients with the family hypermobility of joints in the «case-control ». The second phase includes «prospective cohort controlled» research which means a determination of diagnostic value of CTX-II level and type of OA progression at patients with the family hypermobility of joints. There is a scheme of stratification of the OA risk (includes four groups) and the type of OA progression in patients with the family hypermobility of joints depending on the level of C-terminal telopeptides formed after II type Collagen degradation.