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Frontiers Media, Frontiers in Neuroscience, (9)

DOI: 10.3389/fnins.2015.00145

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Alternative neural circuitry that might be impaired in the development of Alzheimer disease

Journal article published in 2015 by Jesus Avila, George Perry ORCID, Bryan A. Strange, Felix Hernandez
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

It is well established that some individuals with normal cognitive capacity have abundant senile plaques in their brains. It has been proposed that those individuals are resilient or have compensation factors to prevent cognitive decline. In this comment, we explore an alternative mechanism through which cognitive capacity is maintained. This mechanism could involve the impairment of alternative neural circuitry. Also, the proportion of molecules such as Aβ or tau protein present in different areas of the brain could be important.