Dissemin is shutting down on January 1st, 2025

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National Academy of Sciences, Proceedings of the National Academy of Sciences, 47(110), p. 19059-19064, 2013

DOI: 10.1073/pnas.1318022110

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Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation

Journal article published in 2013 by Tracy T. Batchelor, Elizabeth R. Gerstner, Kyrre E. Emblem ORCID, Dan G. Duda, Jayashree Kalpathy-Cramer ORCID, Matija Snuderl, Marek Ancukiewicz, Pavlina Polaskova, Marco C. Pinho, Dominique Jennings, Scott R. Plotkin, Andrew S. Chi, April F. Eichler, Jorg Dietrich, Fred H. Hochberg and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance This study demonstrates that antiangiogenic therapy increases tumor blood perfusion in a subset of newly diagnosed glioblastoma patients, and that it is these patients who survive longer when this expensive and potentially toxic therapy is combined with standard radiation and chemotherapy. This study provides fresh insights into the selection of glioblastoma patients most likely to benefit from antiangiogenic treatments.