Variants in MTNR1B influence fasting glucose levels.

van Duijn, C.; de Geus, Ej J. C.; Prokopenko, Inga; Langenberg, Claudia; Wm, Chen; Florez, Jose C.; Saxena, Richa; Wjh, Penninx; Soranzo, Nicole; Thorleifsson, Gudmar; Van Dujin, C.; Loos, Ruth Jf F.; Manning, Alisa K.; Jc, Florez; Jackson, Anne U.; Aulchenko, Yurii; Rj, Loos; Potter, Simon C.; Erdos, Michael R.; Rjf, Loos; Sanna, Serena; Hottenga, Jouke-Jan; Wheeler, Eleanor; Ak, Manning; Kaakinen, Marika; Au, Jackson; Lyssenko, Valeriya; Chen, Wei-Min; Sc, Potter; Ahmadi, Kourosh; Beckmann, Jacques S.; Jj, Hottenga; Bergman, Richard N.; Bochud, Murielle; Mr, Erdos; Bonnycastle, Lori Ll; Buchanan, Thomas A.; Cao, Antonio; Cervino, Alessandra; Js, Beckmann; Coin, Lachlan; Rn, Bergman; Collins, Francis S.; Crisponi, Laura; Ll, Bonnycastle; Dehghan, Abbas; Deloukas, Panos; Ta, Buchanan; Doney, Alex S. F.; Elliott, Paul; Freimer, Nelson; Fs, Collins; Gateva, Vesela; Ej, de Geus; Herder, Christian; Hofman, Albert; De Geus, Eco J. C.; Hughes, Thomas E.; Hunt, Sarah; Illig, Thomas; As, Doney; Inouye, Michael; Isomaa, Bo; Johnson, Toby; Kong, Augustine; Ejc, Geus de; Krestyaninova, Maria; Kuusisto, Johanna; Asf, Doney; Laakso, Markku; Lim, Noha; Te, Hughes; Lindblad, Ulf; Lindgren, Cecilia M.; Cm, Lindgren; McCann, Owen T.; Mohlke, Karen L.; Morris, Andrew D.; Ot, McCann; Naitza, Silvia; Orrù, Marco; Kl, Mohlke; Palmer, Colin N. A.; Pouta, Anneli; Ad, Morris; Randall, Joshua; Rathmann, Wolfgang; Cna, Palmer; Saramies, Jouko; Scheet, Paul; Cn, Palmer; Scott, Laura J.; Scuteri, Angelo; Lj, Scott; Sharp, Stephen; Sijbrands, Eric; Jh, Smit; Smit, Jan H.; Song, Kijoung; Hm, Stringham; Steinthorsdottir, Valgerdur; Stringham, Heather M.; Ag, Uitterlinden; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Bf, Voight; Uitterlinden, Andre G.; Voight, Benjamin F.; Erich Wichmann, H.; Waterworth, Dawn; Wichmann, He-Erich; Cm, Witteman; Willemsen, Gonneke; Witteman, Jacqueline C. M.; He, Wichmann; Yuan, Xin; Zhao, Jing Hua; Jc, Witteman; Zeggini, Eleftheria; Schlessinger, David; Sandhu, Manjinder; Jh, Zhao; Boomsma, Dorret I.; Uda, Manuela; Di, Boomsma; Spector, Tim D.; Penninx, Brenda Wjh J. H.; Td, Spector; Altshuler, David; Vollenweider, Peter; Bw, Penninx; Jarvelin, Marjo Riitta; Lakatta, Edward; Mr, Jarvelin; Waeber, Gerard; Fox, Caroline S.; Cs, Fox; Peltonen, Leena; Groop, Leif C.; Lc, Groop; Mooser, Vincent; Cupples, La Adrienne; La, Cupples; Thorsteinsdottir, Unnur; Adrienne Cupples, L.; Boehnke, Michael; Barroso, Ines S.; Rm, Watanabe; Mi, McCarthy; Dupuis, Josee; Watanabe, Richard M.; Nj, Wareham; Stefansson, Kari; McCarthy, Mark I.; Jb, Meigs; Wareham, Nicholas J.; Meigs, James B.; Abecasis, Goncalo R.; Gr, Abecasis; Others,

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Inga Prokopenko
van Duijn et al., 2008

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@article{van Duijn2008,
  abstract = {To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10(-15)). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 x 10(-7)) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci.},
  author = {van Duijn, C. and de Geus, Ej J. C. and Prokopenko, Inga and Langenberg, Claudia and Wm, Chen and Florez, Jose C. and Saxena, Richa and Wjh, Penninx and Soranzo, Nicole and Thorleifsson, Gudmar and Van Dujin, C. and Loos, Ruth Jf F. and Manning, Alisa K. and Jc, Florez and Jackson, Anne U. and Aulchenko, Yurii and Rj, Loos and Potter, Simon C. and Erdos, Michael R. and Rjf, Loos and Sanna, Serena and Hottenga, Jouke-Jan and Wheeler, Eleanor and Ak, Manning and Kaakinen, Marika and Au, Jackson and Lyssenko, Valeriya and Chen, Wei-Min and Sc, Potter and Ahmadi, Kourosh and Beckmann, Jacques S. and Jj, Hottenga and Bergman, Richard N. and Bochud, Murielle and Mr, Erdos and Bonnycastle, Lori Ll and Buchanan, Thomas A. and Cao, Antonio and Cervino, Alessandra and Js, Beckmann and Coin, Lachlan and Rn, Bergman and Collins, Francis S. and Crisponi, Laura and Ll, Bonnycastle and Dehghan, Abbas and Deloukas, Panos and Ta, Buchanan and Doney, Alex S. F. and Elliott, Paul and Freimer, Nelson and Fs, Collins and Gateva, Vesela and Ej, de Geus and Herder, Christian and Hofman, Albert and De Geus, Eco J. C. and Hughes, Thomas E. and Hunt, Sarah and Illig, Thomas and As, Doney and Inouye, Michael and Isomaa, Bo and Johnson, Toby and Kong, Augustine and Ejc, Geus de and Krestyaninova, Maria and Kuusisto, Johanna and Asf, Doney and Laakso, Markku and Lim, Noha and Te, Hughes and Lindblad, Ulf and Lindgren, Cecilia M. and Cm, Lindgren and McCann, Owen T. and Mohlke, Karen L. and Morris, Andrew D. and Ot, McCann and Naitza, Silvia and Orrù, Marco and Kl, Mohlke and Palmer, Colin N. A. and Pouta, Anneli and Ad, Morris and Randall, Joshua and Rathmann, Wolfgang and Cna, Palmer and Saramies, Jouko and Scheet, Paul and Cn, Palmer and Scott, Laura J. and Scuteri, Angelo and Lj, Scott and Sharp, Stephen and Sijbrands, Eric and Jh, Smit and Smit, Jan H. and Song, Kijoung and Hm, Stringham and Steinthorsdottir, Valgerdur and Stringham, Heather M. and Ag, Uitterlinden and Tuomi, Tiinamaija and Tuomilehto, Jaakko and Bf, Voight and Uitterlinden, Andre G. and Voight, Benjamin F. and Erich Wichmann, H. and Waterworth, Dawn and Wichmann, He-Erich and Cm, Witteman and Willemsen, Gonneke and Witteman, Jacqueline C. M. and He, Wichmann and Yuan, Xin and Zhao, Jing Hua and Jc, Witteman and Zeggini, Eleftheria and Schlessinger, David and Sandhu, Manjinder and Jh, Zhao and Boomsma, Dorret I. and Uda, Manuela and Di, Boomsma and Spector, Tim D. and Penninx, Brenda Wjh J. H. and Td, Spector and Altshuler, David and Vollenweider, Peter and Bw, Penninx and Jarvelin, Marjo Riitta and Lakatta, Edward and Mr, Jarvelin and Waeber, Gerard and Fox, Caroline S. and Cs, Fox and Peltonen, Leena and Groop, Leif C. and Lc, Groop and Mooser, Vincent and Cupples, La Adrienne and La, Cupples and Thorsteinsdottir, Unnur and Adrienne Cupples, L. and Boehnke, Michael and Barroso, Ines S. and Rm, Watanabe and Mi, McCarthy and Dupuis, Josee and Watanabe, Richard M. and Nj, Wareham and Stefansson, Kari and McCarthy, Mark I. and Jb, Meigs and Wareham, Nicholas J. and Meigs, James B. and Abecasis, Goncalo R. and Gr, Abecasis and Others, },
  doi = {10.1038/ng.290},
  month = {dec},
  title = {Variants in MTNR1B influence fasting glucose levels.},
  url = {http://europepmc.org/articles/pmc2682768?pdf=render},
  year = {2008}
}

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Variants in MTNR1B influence fasting glucose levels.

Journal article published in 2008 by C. van Duijn, Ej J. C. de Geus, Inga Prokopenko

, Claudia Langenberg, Chen Wm, Jose C. Florez, Richa Saxena, Penninx Wjh, Nicole Soranzo, Gudmar Thorleifsson, C. Van Dujin, Ruth Jf F. Loos, Alisa K. Manning, Florez Jc, Anne U. Jackson and other authors. C. van Duijn, Ej J. C. de Geus, Inga Prokopenko

, Claudia Langenberg, Chen Wm, Jose C. Florez, Richa Saxena, Penninx Wjh, Nicole Soranzo, Gudmar Thorleifsson, C. Van Dujin, Ruth Jf F. Loos, Alisa K. Manning, Florez Jc, Anne U. Jackson, Yurii Aulchenko, Loos Rj, Simon C. Potter, Michael R. Erdos, Loos Rjf, Serena Sanna

, Jouke-Jan Hottenga, Eleanor Wheeler, Manning Ak, Marika Kaakinen

, Jackson Au, Valeriya Lyssenko, Wei-Min Chen, Potter Sc, Kourosh Ahmadi, Jacques S. Beckmann

, Hottenga Jj, Richard N. Bergman, Murielle Bochud, Erdos Mr, Lori Ll Bonnycastle, Thomas A. Buchanan, Antonio Cao, Alessandra Cervino, Beckmann Js, Lachlan Coin

, Bergman Rn, Francis S. Collins, Laura Crisponi, Bonnycastle Ll, Abbas Dehghan

, Panos Deloukas

, Buchanan Ta, Alex S. F. Doney, Paul Elliott, Nelson Freimer, Collins Fs, Vesela Gateva, de Geus Ej, Christian Herder, Albert Hofman, Eco J. C. De Geus, Thomas E. Hughes, Sarah Hunt

, Thomas Illig, Doney As, Michael Inouye, Bo Isomaa, Toby Johnson

, Augustine Kong, Geus de Ejc, Maria Krestyaninova, Johanna Kuusisto, Doney Asf, Markku Laakso, Noha Lim, Hughes Te, Ulf Lindblad, Cecilia M. Lindgren, Lindgren Cm, Owen T. McCann, Karen L. Mohlke, Andrew D. Morris, McCann Ot, Silvia Naitza, Marco Orrù, Mohlke Kl, Colin N. A. Palmer, Anneli Pouta, Morris Ad, Joshua Randall, Wolfgang Rathmann, Palmer Cna, Jouko Saramies, Paul Scheet, Palmer Cn, Laura J. Scott, Angelo Scuteri, Scott Lj, Stephen Sharp, Eric Sijbrands, Smit Jh, Jan H. Smit, Kijoung Song, Stringham Hm, Valgerdur Steinthorsdottir

, Heather M. Stringham, Uitterlinden Ag, Tiinamaija Tuomi, Jaakko Tuomilehto, Voight Bf, Andre G. Uitterlinden, Benjamin F. Voight, H. Erich Wichmann, Dawn Waterworth, He-Erich Wichmann, Witteman Cm, Gonneke Willemsen, Jacqueline C. M. Witteman, Wichmann He, Xin Yuan, Jing Hua Zhao, Witteman Jc, Eleftheria Zeggini

, David Schlessinger, Manjinder Sandhu, Zhao Jh, Dorret I. Boomsma, Manuela Uda, Boomsma Di, Tim D. Spector, Brenda Wjh J. H. Penninx, Spector Td, David Altshuler, Peter Vollenweider, Penninx Bw, Marjo Riitta Jarvelin, Edward Lakatta

, Jarvelin Mr, Gerard Waeber, Caroline S. Fox, Fox Cs, Leena Peltonen, Leif C. Groop, Groop Lc, Vincent Mooser, La Adrienne Cupples

, Cupples La, Unnur Thorsteinsdottir, L. Adrienne Cupples, Michael Boehnke, Ines S. Barroso, Watanabe Rm, McCarthy Mi, Josee Dupuis, Richard M. Watanabe, Wareham Nj, Kari Stefansson, Mark I. McCarthy, Meigs Jb, Nicholas J. Wareham, James B. Meigs, Goncalo R. Abecasis, Abecasis Gr, Others

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Abstract

To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 x 10(-50)) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 x 10(-15)). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 x 10(-7)) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 x 10(-57)) and GCK (rs4607517, P = 1.0 x 10(-25)) loci.

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Variants in MTNR1B influence fasting glucose levels.

Abstract