Published in
Hindawi, Journal of Chemistry, (2014), p. 1-8, 2014
DOI: 10.1155/2014/457430
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Synthesis, Single Crystal X-Ray Structure, and Antimicrobial Activity of 6-(1,3-Benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one
,
Nasser R. El Brollosy,
Amany L. Kansoh,
Hazem A. Ghabbour,
Reem I. Al Wabli,
Hoong-Kun Fun
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Abstract
Synthesis, X-ray structure and antimicrobial activity of 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-{[2-(morpholin-4-yl)ethyl]sulfanyl}pyrimidin-4(3H)-one (8) are reported. Compound8exhibited activity towardsS. aureuswith MIC value of 0.0619 μmol/mL while it showed activity towardsB. subtilis,B. cereus,C. albicans, andA. nigerwith MIC = 0.1859 μmol/mL. Single crystal X-ray structure of the title compound8confirmed itsS-alkylation. The title compound crystallizes in the triclinic,P-1,a=11.1220(5) Å,b=12.2241(5) Å,c=21.5246(9) Å,α=88.958(2)°,β=79.836(2)°,γ=79.384(2)°,V=2830.9(2) Å3,Z=6,R(F)=0.046,wR(F2)=0.110,T=100 K. The crystal structure is stabilized by weak intermolecular C–H⋯O and N–H⋯O hydrogen interactions.