This study investigated the formation of secondary pollutants resulting from household product use in the presence of ozone. Experiments were conducted in a 50-m3 chamber simulating a residential room. The chamber was operated at conditions relevant to US residences in polluted areas during warm-weather seasons: an air exchange rate of 1.0 h−1 and an inlet ozone concentration of approximately 120 ppb, when included. Three products were used in separate experiments. An orange oil-based degreaser and a pine oil-based general-purpose cleaner were used for surface cleaning applications. A plug-in scented-oil air freshener (AFR) was operated for several days. Cleaning products were applied realistically with quantities scaled to simulate residential use rates. Concentrations of organic gases and secondary organic aerosol from the terpene-containing consumer products were measured with and without ozone introduction. In the absence of reactive chemicals, the chamber ozone level was approximately 60 ppb. Ozone was substantially consumed following cleaning product use, mainly by homogeneous reaction. For the AFR, ozone consumption was weaker and heterogeneous reaction with sorbed AFR-constituent VOCs was of similar magnitude to homogeneous reaction with continuously emitted constituents. Formaldehyde generation resulted from product use with ozone present, increasing indoor levels by the order of 10 ppb. Cleaning product use in the presence of ozone generated substantial fine particle concentrations (more than 100 μg m−3) in some experiments. Ozone consumption and elevated hydroxyl radical concentrations persisted for 10–12 h following brief cleaning events, indicating that secondary pollutant production can persist for extended periods.