Importance of the TopicSoft tissue injuries represent more than 50% of all musculoskeletal injuries reported each year in the United States [8]. The diagnosis and management of such injuries represent a substantial financial burden, estimated at more than USD 15.8 billion annually [6]. The use of autologous blood concentrates, particularly platelet-rich plasma (PRP), has exponentially grown as a result of significant media attention and use among high-level athletes [9]. While originally used to manage dermatologic and oromaxillofacial conditions, musculoskeletal applications related to bone and soft tissue injury have become widespread [9]. The market for PRP was valued at USD 45 million in 2009 and is expected to be worth more than USD 120 million by 2016 [7].PRP is defined as a sample of autologous blood with supraphysiological concentrations of platelets [2]. Once activated, platelets release bioactive proteins and growth factors that are thought to aid and promote healing [2], but ...