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Medycyna Praktyczna, Polish Archives of Internal Medicine, 5(124), p. 264-269

DOI: 10.20452/pamw.2257

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Relationship between everyday use cosmetics and female breast cancer

Journal article published in 2014 by Ewa Konduracka, Krzysztof Krzemieniecki, Grzegorz Gajos ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Data of the European Cancer Registries indicate that the incidence of breast cancer, the most common cancer among women, tends to increase not only in postmenopausal but also in very young women. The potential causes of breast cancer are genetic predisposition, long-term hormonal replacement therapy, different environmental factors (air pollution, agrochemicals, alcohol) . The controversial results of several studies suggest that certain consumer products (including cosmetic ingredients) may be linked to breast cancer. Some of them, such as ethylene oxide, have recently been classified by the International Agency for Research for Cancer as carcinogenic and mutagenic to humans, with sufficient evidence of carcinogenicity for breast cancer. Other ingredients, such as xenoestrogens, are chemicals which have estrogen-like effect or disrupt the normal metabolism of the natural estrogen and thus act as carcinogens. Some of them have been shown to result in DNA damage in animal and human mammary epithelial cells and, therefore, have the potential to generate genomic instability in breast tissues. Examples of such substances are numerous chemicals with estrogenic properties such as parabens, aluminium salts, phthalates, and bisophenol. Although the published studies have limitations such as the lack of epidemiological data in humans or the fact that they do not investigate the effects of a mixture of chemicals on the incidence of breast cancer. The results of the present study incline to the permanent analysis of the effects of diverse environmental factors, which, in addition to a genetic predisposition and natural aging, may contribute to the increased incidence of cancer.