Transient CC involvement has been reported in encephalopathies/encephalitis of different etiologies. Here we report 2 patients with AFE, who showed transient pancallosal involvement with restricted diffusion on neuroimaging. Both patients had excellent clinical outcomes: The lesion disappeared completely in 1, though there was mild residual gliosis in the other. Serology for dengue virus was positive in 1 of the patients.