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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 3(45), p. 973-975, 2001

DOI: 10.1128/aac.45.3.973-975.2001

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Restoration of Vancomycin Susceptibility in Enterococcus faecalis by Antiresistance Determinant Gene Transfer

Journal article published in 2001 by C. Torres Viera, S. Tsiodras ORCID, H. S. Gold, E. P. G. Coakley, C. Wennersten, G. M. Eliopoulos, R. C. Moellering, R. T. Inouye
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We assessed the ability of gene transfer to reverse vancomycin resistance in class A (VanA) glycopeptide-resistant Enterococcus faecalis . Recombinant shuttle vectors containing a vanH promoter- vanA antisense gene cassette fully restored vancomycin susceptibility through a combined transcriptional activator binding domain decoy and inducible vanA antisense RNA effect.