Dissemin is shutting down on January 1st, 2025

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MDPI, Plants, 3(2), p. 371-378, 2013

DOI: 10.3390/plants2030371

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In vitro cytotoxic activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 cell lines

Journal article published in 2013 by Filip Grbović, Milan S. Stanković ORCID, Milena Ćurčić, Nataša Đorđević, Dragana Šeklić ORCID, Marina Topuzović ORCID, Snežana Marković ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 and MDA-MB-231 cell line in vitro. In order to determine the cytotoxic effects we used an MTT viability assay. The results showed that cell growth is significantly lower in extract treated cells compared to untreated control. The effect of inhibition of cell growth was higher in the treatment of HCT-116 cell line than in MDA-MB-231. Based on the results it is determined that O. vulgare is a significant source of biologically active substances that have cytotoxic and antiproliferative activity in vitro.