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BMJ Publishing Group, Journal of Clinical Pathology, 9(55), p. 648-655

DOI: 10.1136/jcp.55.9.648

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Cell kinetics and cell cycle regulation in lymphomas

Journal article published in 2002 by S. Lazzi ORCID, P. Tosi, L. Leoncini, C. Bellan
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The proliferative indices of non-Hodgkin's lymphomas are useful prognostic indicators and provide information independent of other histological and clinical variables. However, proliferative indices alone do not suffice to characterise cell growth. A high cell production rate may be compensated, almost or fully, by a high cell deletion rate. A re-evaluation of parameters of cell kinetics in view of our increasing knowledge of the molecular pathways of cell cycle control may provide more prognostic information for the management of patients with malignant lymphomas.