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Taylor and Francis Group, OncoImmunology, 3(2), p. e23336

DOI: 10.4161/onci.23336

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Non-classical MHC Class I molecules regulating natural killer cell function

Journal article published in 2013 by Mark J. Smyth, Lucy C. Sullivan, Andrew G. Brooks, Daniel M. Andrews ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Natural killer (NK) cells possess effector and immunoregulatory functions that are controlled by a myriad of receptor-ligand pairs, including human killer inhibitory receptor (KIR) and mouse Ly49-MHC class I interactions. We have recently shown that the NK cell inhibitory molecule Ly49A binds the non-classical MHC molecule H2-M3, thus regulating host innate immune responses to tumor initiation and metastasis.