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Frontiers Media, Frontiers in Nutrition, (1), 2014

DOI: 10.3389/fnut.2014.00022

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The Effect of BCMO1 Gene Variants on Macular Pigment Optical Density in Young Healthy Caucasians

Journal article published in 2014 by Zachary Kyle-Little, Andrew J. Zele, C. Phillip Morris ORCID, Beatrix Feigl
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Serum lutein (L) and zeaxanthin (Z) positively correlate with macular pigment optical density (MPOD); hence, the latter is a valuable indirect tool for measuring L and Z content in the macula. L and Z have been attributed antioxidant capacity and protection from certain retinal diseases but their uptake within the eye is thought to depend on genetic, age, and environmental factors. In particular, gene variants within beta-carotene monooxygenase (BCMO1) are thought to modulate MPOD in the macula.