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Mary Ann Liebert, Antioxidants and Redox Signaling, 3(24), p. 157-170

DOI: 10.1089/ars.2014.6120

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AMPK phosphorylation modulates pain by activation of NLRP3-inflammasome

Journal article published in 2015 by Angel M. Carrión, Juan Garrido-Maraver, Fabiola Marín-Aguilar, Lourdes Román-Malo, Jesus Ruiz-Cabello, Ognjen Culic, Bernhard Ryffel, François Ghiringhelli, José Antonio Sánchez-Alcazar, Elisabet Alcocer-Gómez, Mario D. Cordero, Pedro Bullon ORCID, Lionel Apetoh ORCID, Maurizio Battino
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Aims: Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases. In this study, we investigated the role of AMPK/NLRP3 inflammasome axis in the molecular mechanism underlying pain perception. Results: Impairment in AMPK activation induced by compound C or sunitinib, two AMPK inhibitors, provoked hyperalgesia in mice (p