Published in
Wiley, Annals of Neurology, 3(69), p. 481-492, 2010
DOI: 10.1002/ana.22109
Links
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.research.ed.ac.uk] | PDF
- [www.pure.ed.ac.uk] | PDF
- [europepmc.org] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
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Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
Journal article published in 2010 by
Graham R. Campbell,
Iryna Ziabreva,
Amy K. Reeve,
Kim J. Krishnan,
Richard Reynolds 
,
Owen Howell,
Hans Lassmann,
Doug M. Turnbull,
Don J. Mahad
,
Owen Howell,
Hans Lassmann,
Doug M. Turnbull,
Don J. Mahad
This paper is made freely available by the publisher.
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Abstract
Objective Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely, mitochondria harbor their own mitochondrial DNA (mtDNA), essential for maintaining a healthy central nervous system. We explored mitochondrial respiratory chain activity and mtDNA deletions in single neurons from secondary progressive MS (SPMS) cases.