Published in

Wiley, Angewandte Chemie International Edition, 47(45), p. 7952-7955, 2006

DOI: 10.1002/anie.200603100

Wiley, Angewandte Chemie, 47(118), p. 8120-8123, 2006

DOI: 10.1002/ange.200603100

Links

Tools

Export citation

Search in Google Scholar

Snapshots of the Reaction Mechanism of Matrix Metalloproteinases

Journal article published in 2006 by Ivano Bertini, Vito Calderone, Marco Fragai ORCID, Claudio Luchinat ORCID, Massimiliano Maletta, Kwon Joo Yeo
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

(Figure Presented) The series of events that occur in the catalytic cycle of matrix metalloproteinases were modeled on the basis of X-ray crystal structures of the active, uninhibited enzymes and of the same enzymes following the hydrolysis of a peptide substrate. After the peptide bond has been broken, both peptide fragments remain bound to the protein initially (see structure of the active-site cavity of the enzyme MMP-12 immediately after substrate hydrolysis).