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Taylor and Francis Group, Nucleosides, Nucleotides and Nucleic Acids, 10-12(26), p. 1295-1299

DOI: 10.1080/15257770701530541

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Optical tweezers as a probe for oligodeoxyribonucleotide structuration

Journal article published in 2007 by Nicola Borbone, Giorgia Oliviero, Jussara Amato, Gennaro Piccialli ORCID, Luciano Mayol ORCID, Lisa Miccio, Giuseppe Pescen, Antonio Sasso
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The aim of this work is to investigate if the optical tweezers (OT) are suitable as a diagnostic tool for monitoring the oligodeoxyribonucleotide (ODN) structural behavior in solution. Preliminary experiments, performed on the quadruplex formed by the ODN sequence TGGGGT, showed that the OT can be used as a probe for ODN structuration by monitoring the medium viscosity changes associated with ODN folding-unfolding processes.