Dissemin is shutting down on January 1st, 2025

Published in

Cell Press, Cell Metabolism, 2(16), p. 135-137, 2012

DOI: 10.1016/j.cmet.2012.07.012

Links

Tools

Export citation

Search in Google Scholar

TXNIP switches tracks toward a terminal UPR

Journal article published in 2012 by Tracy G. Anthony ORCID, Ronald C. Wek
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate β cell death.