Introduction Quality of life is associated with the perceptions of individuals about their feelings, values, expectations and social standards. This concept can be influenced by several factors, including psychological, social, physical and cultural. The investigation of factors that can contribute to the quality of life is important for understanding this concept. Body shape concern and perceived health competence are factors that can impact in the daily lives of individuals, mainly university students [1,2]. The aim of this study was to investigate the contribution of body shape concern and perceived health competence to Portuguese Pharmacy college students' quality of life. Methods The study was idealized as a transnational research study, with information being collected in parallel in two countries (Portugal and Brazil), using samples with similar characteristics. The Portuguese version of scales Body Shape Questionnaire (short version)–BSQ [1], Perceived Health Competence Scale– PHCS [2] and Short Questionnaire of World Health Organization Quality of Life–WHOQOL-BREF [3] were used to estimate the constructs body shape concern, perceived health competence and quality of life, respectively. The confirmatory factor analysis (CFA) of scales was carried out. The goodness-of-fit indices chi-square by degrees of freedom (χ 2 /df), comparative fit index (CFI), normed fit index (NFI), and root mean square error of approximation (RMSEA) were used. The reliability was assessed by standardized Cronbach's alpha coefficient (α). The algorithm, generated in the CFA for each construct, by regression weights matrix of the model, was used to create a structural model. The quality of life was used how dependent variable and the body image concern and the perceived health competence how independent variables. The multiple linear regression, with estimation of the parameters by the maximum likelihood, was used. The Mahalanobis distance was used for identification of outliers. The significance of structural model was assessed by regression coefficient (R 2). The significance of trajectories (β) was assessed by z test. A significance level of 5% was used [4]. Results and Discussion Although this is part of a larger study, only results pertaining to data collected from ISCSEM will be presented at this congress. A total of 184 students (78.8% female) of Pharmacy participated of study. The average age of participants was 21.52±2.62 years. The scales BSQ, PHCS and WHOQOL-BREF