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Nature Research, Nature Reviews Drug Discovery, 9(7), p. 738-745, 2008

DOI: 10.1038/nrd2606

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Perspectives on NMR in drug discovery: a technique comes of age

Journal article published in 2008 by Maurizio Pellecchia, Ivano Bertini, David Cowburn, Claudio Dalvit, Ernest Giralt, Wolfgang Jahnke, Thomas L. James, Steve W. Homans, Horst Kessler, Claudio Luchinat ORCID, Bernd Meyer, Hartmut Oschkinat, Jeff Peng, Harald Schwalbe ORCID, Gregg Siegal
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.