The evolution of nuclear disintegration mechanisms with increasing excitation energy, from com-pound nucleus to multifragmentation, has been studied by using the Statistical Multifragmentation Model (SMM) within a micro-canonical ensemble. We discuss the observable characteristics as functions of excitation energy in multifragmentation, concentrating on the isospin dependence of the model in its decaying mechanism and break-up fragment configuration by comparing the A0 = 200, Z0 = 78 and A0 = 200, Z0 = 100 systems. The calculations indicate that the neutron-rich system (Z0 = 78) translates to a fission-like process from evaporation later than the symmetric nucleus at a lower excitation energy, but gets a larger average multiplicity as the excitation energy increases above 1.0 MeV/u.