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American Association of Pharmaceutical Scientists, AAPS PharmSciTech, 3(6), p. E367-E371

DOI: 10.1208/pt060346

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Optimization of tablets containing a high dose of spray-dried plant extract: A technical note

Journal article published in 2005 by Luiz Alberto Lira Soares ORCID, Luiz Alberto Lira Soares, George González Ortega, Pedro Ros Petrovick, Peter Christian Schmidt
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Optimization of CSD and CMC-Na in tablet formulations containing a high dose of SDE fromM ilicifolia was performed by central composite design (CCD) and response surface methodology (RSM). The study demonstrated that CSD affected mainly the hardness and friability, while CMC-Na modified the disintegration times. The optimum formula for minimum disintegration time and friability, and maximum crushing strength, was found to contain 1.2% (wt/wt) of CSD and 5.0% (wt/wt) of CMC-Na. At these conditions, the tablet shows a crushing strength of 107.9 N, a friability of 0.56% (wt/wt), and a maximum disintegration time of 6.8 minutes.