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Taylor and Francis Group, OncoImmunology, 2(3), p. e27358

DOI: 10.4161/onci.27358

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A novel pathway links telomeres to NK-cell activity

Journal article published in 2014 by Julien Cherfils-Vicini, Pasquale Zizza ORCID, Eric Gilson, Annamaria Biroccio ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Here, we describe a model in which telomeric repeat-binding factor 2 (TERF2) can control tumorigenesis not only via cancer cell-intrinsic mechanisms but also via non-cancer cell autonomous pathways. Indeed, we have recently shown that TERF2 regulates tissue homeostasis as it promotes the elimination of aged, damaged, and neoplastic cells by the immune system, opening the way to new therapeutic options against cancer.