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BMJ Publishing Group, Journal of Clinical Pathology, 7(54), p. 539-542

DOI: 10.1136/jcp.54.7.539

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p53 codon 72 polymorphism and human papillomavirus associated skin cancer

Journal article published in 2001 by E. W. Kay, M. Leader, G. M. Murphy, D. P. O'Connor ORCID, Gregory Julian Atkins, M. J. Mabruk
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background/Aims—Non-melanoma skin cancers frequently harbour multiple human papillomavirus (HPV) types. A recent report suggests that a polymorphism of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in HPV associated malignancies. This study aimed to determine the following: (1) the relation between HPV infection and the development of cutaneous squamous cell carcinoma (SCC), and (2) whether there is a correlation between p53 codon 72 polymorphism and the development of SCC.